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Mar 24, 2022

The first male contraceptive that won't affect men's hormone levels is on the horizon. Francesca Fiorentini and David Shuster break it down on The Damage Report.
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Read more here:
A Birth Control Pill for Men Could Start Human Trials This Year - https://gizmodo.com/a-birth-control-pill-for-men-could-start-human-trials-t-1848685598
"Scientists are still racing to create the first male contraceptive that isn’t a condom or surgery. In new preliminary research, a team says they’ve developed a non-hormonal form of male birth control, one that kept lab mice sterile for four to six weeks with seemingly no side effects. Early human trials of the pill are expected to begin by the end of the year.
The proposed contraceptive is the product of researchers at the University of Minnesota, who say it works by targeting how our bodies interact with vitamin A, known to be essential to fertility in mammals. Diets deficient in vitamin A have been linked to sterility, for instance. After a lengthy search, they found an experimental compound that blocks a protein responsible for binding to a form of vitamin A (retinoic acid) in our cells, known as retinoic acid receptor alpha (RAR-α). RAR-α is one of three proteins with a similar function, and the hope is that its selective blocking is enough to induce long-lasting but reversible sterility while causing little to no off-target effects elsewhere."
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